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sparsentan will lower the level or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and cuts down efficacy connected with these substrates.Renal Impairment: Modafinil should be employed with caution in clients with significant renal impairm